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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Gpx3 - glutathione peroxidase 3
Alias:
Gpxp
GPx-3
GPx-P
GSHPx-3
GSHPx-P
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于谷胱甘肽过氧化物酶家族,该家族成员通过谷胱甘肽催化有机氢过氧化物和过氧化氢(H2O2)的还原,从而保护细胞免受氧化损伤。这个基因家族在脊椎动物中存在几种同工酶,它们的细胞定位和底物特异性各不相同。这种同工酶是分泌型的,主要在大鼠肾脏中表达,似乎是血浆中该酶的主要来源。这种同工酶的调节紊乱与肥胖相关的代谢并发症有关。这种同工酶也是一种硒蛋白,其活性部位含有罕见的氨基酸硒代半胱氨酸(Sec)。Sec由UGA密码子编码,该密码子通常表示翻译终止。硒蛋白mRNA的3'UTR含有保守的茎环结构,称为Sec插入序列(SECIS)元素,该元素对于识别UGA作为Sec密码子而不是作为停止信号是必要的。[RefSeq,2016年8月提供]
Related ID:
NCBI:64317
ENSEMBL:ENSRNOG00000052564
UNIPROT:P23764
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
64317
1
5
8072 bp
25.42
11
2
Gpx3 Genetics information (+)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
Protein
Length(aa)
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* This data comes from NCBI.
Gene Expression
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Name
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