大鼠

Gpx3 - glutathione peroxidase 3

Alias:
Gpxp
GPx-3
GPx-P
GSHPx-3
GSHPx-P
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于谷胱甘肽过氧化物酶家族,该家族成员通过谷胱甘肽催化有机氢过氧化物和过氧化氢(H2O2)的还原,从而保护细胞免受氧化损伤。这个基因家族在脊椎动物中存在几种同工酶,它们的细胞定位和底物特异性各不相同。这种同工酶是分泌型的,主要在大鼠肾脏中表达,似乎是血浆中该酶的主要来源。这种同工酶的调节紊乱与肥胖相关的代谢并发症有关。这种同工酶也是一种硒蛋白,其活性部位含有罕见的氨基酸硒代半胱氨酸(Sec)。Sec由UGA密码子编码,该密码子通常表示翻译终止。硒蛋白mRNA的3'UTR含有保守的茎环结构,称为Sec插入序列(SECIS)元素,该元素对于识别UGA作为Sec密码子而不是作为停止信号是必要的。[RefSeq,2016年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
1
5
8072 bp
25.42
11
2

Gpx3 Genetics information (+)

mRatBN7.2

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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