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中文人类
IFIH1 - Interferon Induced With Helicase C Domain 1
Alias:
AGS7
Hlcd
MDA5
IMD95
MDA-5
RLR-2
IDDM19
SGMRT1
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IFIH1编码MDA5，MDA5是病毒RNA的细胞内传感器，能触发先天免疫反应。MDA5能感知RNA的长度和二级结构，结合dsRNA寡核苷酸，具有修饰的DExD/H-box螺旋酶核心和C端结构域，从而引发包括干扰素在内的促炎反应。已证实冠状病毒（CoVs）以及其他病毒家族能逃避MDA5依赖的干扰素反应，从而阻碍对感染的先天免疫反应。MDA5在增强疟疾感染中自然杀伤细胞功能方面发挥重要作用。除了其在抗病毒反应中的保护作用外，MDA5还与自身免疫和自身炎症疾病如1型糖尿病、系统性红斑狼疮和Aicardi-Goutieres综合征有关[由RefSeq，2020年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
IFIH1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
