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中文人类
NOD2 - Nucleotide Binding Oligomerization Domain Containing 2
Alias:
CD
ACUG
BLAU
IBD1
YAOS
BLAUS
NLRC2
NOD2B
CARD15
CLR16.3
PSORAS1
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这个基因是Nod1/Apaf-1家族的成员，编码一个具有两个天冬氨酸酶招募结构域（CARD）和六个富含亮氨酸的重复序列（LRR）的蛋白质。该蛋白质主要在周围血白细胞中表达。它通过识别来自内源性细菌脂多糖（LPS）的胞壁肽（MDP）并激活NFKB蛋白质，在免疫应答中对内源性细菌脂多糖（LPS）发挥作用。这个基因的突变与克罗恩病和布劳综合征有关。已经发现这个基因有不同的剪接转录变异体，它们编码不同的异构体。[RefSeq，2014年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NOD2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
