人类

SELPLG - Selectin P Ligand

Alias:
CLA
CD162
PSGL1
PSGL-1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一种糖蛋白,作为表达在髓样细胞和刺激T淋巴细胞的细胞粘附分子P-、E-和L-选择素的高亲和力拮抗受体。因此,这种蛋白质在炎症过程中通过将白细胞与表达选择素的激活血小板或内皮细胞连接起来,在白细胞转运中起着关键作用。这种蛋白质需要两种翻译后的修饰,即酪氨酸硫酸化和在其O-连接的糖链上添加唾液酸刘易斯x四糖(sLex),以实现其高亲和力结合活性。这个基因的异常表达和基因中的多态性与先天和适应性免疫反应的缺陷有关。交替剪接导致多个转录变异体。[RefSeq,2011年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
2
12000 bp
43.20
21
--
6
24

SELPLG Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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