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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
SELPLG - Selectin P Ligand
Alias:
CLA
CD162
PSGL1
PSGL-1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一种糖蛋白,作为表达在髓样细胞和刺激T淋巴细胞的细胞粘附分子P-、E-和L-选择素的高亲和力拮抗受体。因此,这种蛋白质在炎症过程中通过将白细胞与表达选择素的激活血小板或内皮细胞连接起来,在白细胞转运中起着关键作用。这种蛋白质需要两种翻译后的修饰,即酪氨酸硫酸化和在其O-连接的糖链上添加唾液酸刘易斯x四糖(sLex),以实现其高亲和力结合活性。这个基因的异常表达和基因中的多态性与先天和适应性免疫反应的缺陷有关。交替剪接导致多个转录变异体。[RefSeq,2011年4月提供]
Related ID:
NCBI:6404
ENSEMBL:ENSG00000110876
HGNC:10722
UNIPROT:Q14242
OMIM:600738
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6404
2
2
12000 bp
43.20
21
--
6
24
SELPLG Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
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Interactions
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Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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