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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
SDC1 - Syndecan 1
Alias:
SDC
CD138
SYND1
syndecan
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种跨膜(I型)肝素硫酸蛋白多糖,是合成糖蛋白家族的一员。Syndecans调节细胞结合、细胞信号传递和细胞骨架组织,并且Syndecan受体是HIV-1 tat蛋白内化的必需成分。Syndecan-1蛋白作为整合膜蛋白发挥作用,并通过其与细胞外基质蛋白受体的参与,参与细胞增殖、细胞迁移和细胞-基质相互作用。已经检测到Syndecan-1表达的改变存在于几种不同的肿瘤类型中。虽然这个基因可能存在几个转录变异体,但迄今为止只描述了两个全长变异体。这两个变异体代表了这个基因的主要变异体,并编码相同的蛋白质。[RefSeq,2008年7月提供]
Related ID:
NCBI:6382
ENSEMBL:ENSG00000115884
HGNC:10658
UNIPROT:P18827
OMIM:186355
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6382
5
5
24679 bp
32.46
18
--
4
15
SDC1 Genetics information (-)
GRCh38
Sequence Homology
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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