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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CXCL11 - C-X-C Motif Chemokine Ligand 11
Alias:
IP9
H174
IP-9
b-R1
I-TAC
SCYB11
SCYB9B
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
化学诱引素是一组小的(大约8到14kD),主要碱性,结构上相关的分子,它们通过与其他7-跨膜,G蛋白耦合受体子集相互作用,调节各种类型的白细胞的细胞运动。化学诱引素在免疫系统的发育,稳态和功能中也起着基本作用,它们对中枢神经系统细胞以及参与血管生成的内皮细胞也有影响。化学诱引素分为两个主要亚家族,CXC和CC。这个抗菌基因是化学诱引素超家族的一个CXC成员。其编码的蛋白质在激活的T细胞中诱导化学趋化反应,并作为CXCR-3的主要配体。编码这种蛋白质的基因包含4个外显子,并至少有三个聚腺苷酸化信号,这可能反映了表达的手机器特异性调节。IFN-γ是这种基因的强有力的转录诱导剂。已经发现这种基因有两个转录变异体,编码不同的异构体。[由RefSeq,2014年10月提供]
Related ID:
NCBI:6373
ENSEMBL:ENSG00000169248
HGNC:10638
UNIPROT:O14625
OMIM:604852
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
6373
2
4
2389 bp
10.37
5
--
--
11
CXCL11 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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* This data comes from NCBI.
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