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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CCL21 - C-C Motif Chemokine Ligand 21
Alias:
ECL
SLC
CKb9
TCA4
6Ckine
SCYA21
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这种抗菌基因是位于染色体9p臂上的几个CC细胞因子基因之一。细胞因子是一类参与免疫调节和炎症过程的分泌蛋白质家族。CC细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。与其他趋化因子相似,这个基因编码的蛋白质抑制血细胞生成并刺激趋化作用。这个蛋白质在体外对胸腺细胞和激活的T细胞有趋化作用,但对B细胞、巨噬细胞或中性粒细胞没有趋化作用。这个基因编码的细胞因子也可能在调节淋巴细胞归巢到二级淋巴器官中发挥作用。它是趋化因子受体7的高亲和力功能性配体,该受体在T和B淋巴细胞上表达,并作为细胞因子家族的另一成员(小诱导性细胞因子A19)的已知受体。[RefSeq,2014年9月提供]
Related ID:
NCBI:6366
ENSEMBL:ENSG00000137077
HGNC:10620
UNIPROT:O00585
OMIM:602737
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
6366
1
4
1132 bp
14.65
6
--
1
12
CCL21 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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* This data comes from NCBI.
Gene Expression
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