人类

CCL5 - C-C Motif Chemokine Ligand 5

Alias:
SISd
eoCP
SCYA5
RANTES
TCP228
D17S136E
SIS-delta
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因是位于17号染色体q臂上的一组化学因子基因之一。化学因子组成一个涉及免疫调节和炎症过程的分泌蛋白质超家族。该超家族根据成熟肽的N端半胱氨酸残基排列分为四个亚家族。这个化学因子是CC亚家族的成员,作为血液单核细胞、记忆T辅助细胞和嗜酸性粒细胞的化学吸引物发挥作用。它导致嗜碱性粒细胞释放组胺并激活嗜酸性粒细胞。这种细胞因子是CD8+细胞产生的主要HIV抑制因子之一。它作为化学因子受体化学因子(C-C基序)受体5(CCR5)的天然配体之一发挥作用,并抑制使用CCR5作为共受体的HIV-1 R5株的体外复制。可变剪接产生多种编码不同异型体的转录变异体。[RefSeq,2013年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
3
8870 bp
9.99
4
1
5
20

CCL5 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
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