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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CCL5 - C-C Motif Chemokine Ligand 5
Alias:
SISd
eoCP
SCYA5
RANTES
TCP228
D17S136E
SIS-delta
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因是位于17号染色体q臂上的一组化学因子基因之一。化学因子组成一个涉及免疫调节和炎症过程的分泌蛋白质超家族。该超家族根据成熟肽的N端半胱氨酸残基排列分为四个亚家族。这个化学因子是CC亚家族的成员,作为血液单核细胞、记忆T辅助细胞和嗜酸性粒细胞的化学吸引物发挥作用。它导致嗜碱性粒细胞释放组胺并激活嗜酸性粒细胞。这种细胞因子是CD8+细胞产生的主要HIV抑制因子之一。它作为化学因子受体化学因子(C-C基序)受体5(CCR5)的天然配体之一发挥作用,并抑制使用CCR5作为共受体的HIV-1 R5株的体外复制。可变剪接产生多种编码不同异型体的转录变异体。[RefSeq,2013年7月提供]
Related ID:
NCBI:6352
ENSEMBL:ENSG00000271503
HGNC:10632
UNIPROT:P13501
OMIM:187011
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6352
2
3
8870 bp
9.99
4
1
5
20
CCL5 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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References Literature
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