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中文人类
BCR - BCR Activator Of RhoGEF And GTPase
Alias:
ALL
CML
PHL
BCR1
D22S11
D22S662
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染色体22和9之间的相互易位产生了费城染色体，通常可在慢性髓细胞白血病患者中发现。该易位的染色体22断裂点位于BCR基因内。该易位产生一个由BCR和ABL基因（染色体9断裂点处的基因）序列编码的融合蛋白。尽管BCR-ABL融合蛋白已得到广泛研究，但正常BCR基因产物的功能尚不清楚。BCR-ABL1的酪氨酸激酶活性不受调控，有助于白血病细胞的永生。BCR蛋白具有丝氨酸/苏氨酸激酶活性，并作为p21rac和其他激酶的GTP酶激活蛋白。已发现该基因编码两种不同的异构体。[RefSeq，2020年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
BCR Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
