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中文人类
ROCK1 - Rho Associated Coiled-coil Containing Protein Kinase 1
Alias:
ROCK-I
P160ROCK
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这个基因编码一个丝氨酸/苏氨酸激酶，当它与GTP结合形式的Rho结合时被激活。小GTP酶Rho在细胞质中来回穿梭，在无活性的GDP结合形式和有活性的GTP结合形式之间调节成纤维细胞的焦点粘附和应力纤维的形成，以及血小板和淋巴细胞的粘附和聚集。Rho在胞质分裂中也起重要作用，并在血清响应因子的转录激活中发挥作用。这个蛋白是Rho的下游效应子，能磷酸化并激活LIM激酶，LIM激酶进而磷酸化cofilin，抑制其促聚烯酸脱聚活性。与这个基因相关的假基因也位于染色体18上。[RefSeq,2015年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ROCK1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
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CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Abundance
Alphabetical
Cell-specific RNA expression
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Abundance
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Regulation
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MGI
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References Literature
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