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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Cd274 - CD274 antigen
Alias:
B7h1
Pdl1
Pdcd1l1
Pdcd1lg1
A530045L16Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是一种免疫抑制受体配体,由造血和非造血细胞表达,如T细胞和B细胞以及各种类型的肿瘤细胞。编码的蛋白质是一种I型跨膜蛋白质,具有免疫球蛋白V样和C样结构域。这个配体与其受体的相互作用抑制T细胞激活和细胞因子的产生。在正常组织的感染或炎症期间,这种相互作用对于通过维持免疫反应的稳态来预防自身免疫非常重要。在肿瘤微环境中,这种相互作用通过抑制细胞毒性T细胞的活性为肿瘤细胞提供免疫逃逸途径。缺乏这个基因的小鼠表现出各种表型,包括异种胎存活率降低和严重的实验性自身免疫性脑脊髓炎。[由RefSeq,2015年9月提供]
Related ID:
NCBI:60533
ENSEMBL:ENSMUSG00000016496
UNIPROT:Q9EP73
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
60533
3
7
26068 bp
32.78
22
14
Cd274 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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