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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
RGS10 - Regulator Of G Protein Signaling 10
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
G蛋白信号调节因子(RGS)家族成员是作为Gα亚基的GTP酶激活蛋白(GAPs)的调节分子。RGS蛋白能够去活化Giα、Goα和Gqα亚型的G蛋白亚基。它们驱动G蛋白进入其失活的GDP结合形式。G蛋白信号调节因子10属于这个家族。所有RGS蛋白共享一个保守的120个氨基酸序列,称为RGS结构域。这种蛋白质特异地与两个相关G蛋白亚基G-alphai3和G-alphaz的活化形式结合,但无法与结构和功能上不同的G-α亚基相互作用。G蛋白信号调节因子10蛋白位于细胞核中。已经发现这个基因的两个转录变异体,编码不同的异构体。[RefSeq,2008年7月提供]
Related ID:
NCBI:6001
ENSEMBL:ENSG00000148908
HGNC:9992
UNIPROT:O43665
OMIM:602856
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6001
2
5
42903 bp
21.21
4
--
4
11
RGS10 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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Name
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Status
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References Literature
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