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中文人类
RB1 - RB Transcriptional Corepressor 1
Alias:
RB
pRb
OSRC
pp110
p105-Rb
PPP1R130
p110-RB1
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这个基因编码的蛋白质是细胞周期的负调控因子，是第一个被发现的肿瘤抑制基因。编码的蛋白质还能稳定恒定的异质染色质，以维持整体的染色质结构。该蛋白质的活性、低磷酸化形式与转录因子E2F1结合。这个基因的缺陷是导致儿童癌症视网膜母细胞瘤（RB）、膀胱癌和骨源性肉瘤的原因。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
RB1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
