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中文人类
RAF1 - Raf-1 Proto-oncogene, Serine/threonine Kinase
Alias:
NS5
CRAF
Raf-1
c-Raf
CMD1NN
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这个基因是病毒raf基因(v-raf)的细胞同源物。编码的蛋白质是一种MAP激酶激酶(MAP3K)，其在与Ras家族膜关联GTP酶直接结合的下游发挥作用。一旦激活，细胞RAF1蛋白可以磷酸化以激活双特异性蛋白激酶MEK1和MEK2，进而磷酸化以激活丝氨酸/苏氨酸特异性蛋白激酶ERK1和ERK2。活化的ERKs是细胞生理学的多效效应物，并在控制细胞分裂周期、凋亡、细胞分化和细胞迁移涉及的基因表达中扮演重要角色。此基因的突变与Noonan综合征5和LEOPARD综合征2有关。[由RefSeq提供，2008年7月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
RAF1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
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Target
Residues
Reference
Score
Related Mouse Models
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Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
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CAS Number
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Phase
Link
References Literature
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