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中文人类
MAP4K2 - Mitogen-activated Protein Kinase Kinase Kinase Kinase 2
Alias:
GCK
BL44
RAB8IP
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这个基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。尽管这种激酶存在于许多组织中，但其表达在淋巴滤泡中仅限于生发中心细胞，可能参与B细胞的分化。这种激酶可以由TNF-α激活，并被证明能特异性地激活MAP激酶。这种激酶还发现与TNF受体相关因子2（TRAF2）相互作用，TRAF2涉及MAP3K1/MEKK1的激活。选择性剪接产生多种转录变异体。[RefSeq，2015年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAP4K2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
