Bcl11b - B cell leukemia/lymphoma 11B

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cell morphogenesis involved in differentiation; and regulation of keratinocyte proliferation. Located in neuron projection and nucleus. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; nose; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BAF chromatin remodeling complex subunit BCL11B). [provided by Alliance of Genome Resources, Apr 2022]