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中文人类
BAX - BCL2 Associated X, Apoptosis Regulator
Alias:
BCL2L4
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这个基因编码的蛋白质属于BCL2蛋白家族。BCL2家族成员形成异源或同源二聚体，并作为参与多种细胞活动的抗凋亡或促凋亡调节剂。这个蛋白质与BCL2形成异源二聚体，并作为凋亡激活剂发挥作用。BAX与BCL2的结合和比例决定了细胞在受到凋亡刺激后的生存或死亡。这个蛋白质已被报道与线粒体电压依赖性阴离子通道（VDAC）相互作用并增加其开放，从而导致膜电位的丧失和细胞色素c的释放。这个基因的表达受肿瘤抑制子P53的调节，并被证明涉及P53介导的凋亡。这个基因有多个可变剪接转录变异体，它们编码不同的异构体。[RefSeq,2019年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
BAX Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
