Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Orthologous to several human genes including ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Apr 2022]