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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PTPRA - Protein Tyrosine Phosphatase Receptor Type A
Alias:
LRP
HLPR
PTPA
HEPTP
HPTPA
RPTPA
PTPRL2
HPTPalpha
R-PTP-alpha
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一员。PTP被认为是调节各种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和癌基因转化。这个PTP包含一个胞外结构域,一个单跨膜片段和两个串联的胞内催化域,因此代表一个受体型PTP。这个PTP已经显示可以脱磷酸化并激活Src家族酪氨酸激酶,并与整合素信号传导、细胞粘附和增殖的调节有关。这个基因的三个可变剪接变异体已经报道,它们编码两种不同的异构体。[由RefSeq,2008年7月提供]
Related ID:
NCBI:5786
ENSEMBL:ENSG00000132670
HGNC:9664
UNIPROT:P18433
OMIM:176884
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5786
27
24
174486 bp
90.72
63
1
7
17
PTPRA Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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