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中文人类
PTAFR - Platelet Activating Factor Receptor
Alias:
PAFR
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这个基因编码一种七跨膜G蛋白偶联受体，对血小板激活因子（PAF）有反应，该受体在细胞膜的脂质raft和/或 caveolae 中定位。PAF（1-0-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）是一种磷脂，在致癌转化、肿瘤生长、血管生成、转移和促炎过程中发挥重要作用。PAF与PAF受体（PAFR）结合会刺激多种信号转导途径，包括磷脂酶C、D、A2、丝裂原活化蛋白激酶（MAPK）和磷脂酰肌醇钙第二信使系统。PAFR激活后，细胞会迅速失去敏感性，这种耐受状态取决于PAFR磷酸化、内化和下调。替代剪接产生多种转录变体。[由RefSeq提供，2011年8月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PTAFR Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Abundance
Alphabetical
Cell-specific RNA expression
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Abundance
Alphabetical
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Regulation
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MGI
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References Literature
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