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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PSMB9 - Proteasome 20S Subunit Beta 9
Alias:
LMP2
PRAAS3
PSMB6i
RING12
beta1i
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
蛋白酶体是一种具有高度有序环形20S核心结构的多催化蛋白酶复合物。核心结构由4个不同亚基环组成,其中2个环由7个α亚基组成,另外2个环由7个β亚基组成。蛋白酶体在真核细胞中高浓度分布,并在非溶酶途径中,通过ATP/泛素依赖的过程切割肽段。修饰后的蛋白酶体,即免疫蛋白酶体,在加工I类MHC肽方面具有重要作用。该基因编码蛋白酶体B型家族的一员,也称为T1B家族,是20S核心β亚基。该基因位于MHC(主要组织相容性复合体)的II类区域。该基因的表达受γ干扰素的诱导,并在免疫蛋白酶体中替换了催化亚基1(蛋白酶体β6亚基)。成熟亚基的产生需要蛋白水解加工。[RefSeq,2010年3月提供]
Related ID:
NCBI:5698
ENSEMBL:ENSG00000240065
HGNC:9546
UNIPROT:P28065
OMIM:177045
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5698
1
6
5660 bp
23.26
14
1
6
24
PSMB9 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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