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Prkn - parkin RBR E3 ubiquitin protein ligase

Alias:
Park
Park2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活蛋白激酶结合活性。参与几个过程,包括细胞对氨基酸刺激的响应;神经元死亡的负调控;以及突触传递的负调控。在神经元死亡负调控的上游或内部发挥作用。位于几个细胞组件中,包括膜性器官的边界膜;膜筏;以及突触后密度。与线粒体共定位。用于研究帕金森病。2型糖尿病的生物标志物。这个基因的人类同源物与帕金森病、帕金森病2和卵巢癌有关。与人类的PRKN(parkin RBR E3泛素蛋白连接酶)正交。[由基因组资源联盟,2022年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
12
12
1193870 bp
51.71
18
5

Prkn Genetics information (-)

mRatBN7.2

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
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