Mtor - mechanistic target of rapamycin kinase

Enables several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular protein metabolic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in cytosol and nucleus. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]