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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Cldn18 - claudin 18
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码claudin家族的一员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞片之间的胞间空间。它们还在维持细胞极性和信号传导中起到关键作用。这个基因是T/EBP/NKX2.1同源域转录因子的下游靶基因。已经发现了四种可变剪接转录变异体,分别由不同的启动子和可变剪接产生,分别编码两种肺特异性异构体和两种胃特异性异构体。这个基因也在结肠、内耳和皮肤中表达,并且在实验性结肠炎和溃疡性结肠炎中其表达都增加。[RefSeq,2010年8月提供]
Related ID:
NCBI:56492
ENSEMBL:ENSMUSG00000032473
UNIPROT:P56857
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
56492
4
5
26472 bp
28.12
11
15
Cldn18 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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