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Cldn18 - claudin 18

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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码claudin家族的一员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞片之间的胞间空间。它们还在维持细胞极性和信号传导中起到关键作用。这个基因是T/EBP/NKX2.1同源域转录因子的下游靶基因。已经发现了四种可变剪接转录变异体,分别由不同的启动子和可变剪接产生,分别编码两种肺特异性异构体和两种胃特异性异构体。这个基因也在结肠、内耳和皮肤中表达,并且在实验性结肠炎和溃疡性结肠炎中其表达都增加。[RefSeq,2010年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
4
5
26472 bp
28.12
11
15

Cldn18 Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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