Log In|Sign Up
中文人类
MASP1 - MBL Associated Serine Protease 1
Alias:
3MC1
MAP1
MASP
RaRF
CRARF
MAP-1
MASP3
MAp44
PRSS5
CRARF1
MASP-3
Favorite
这个基因编码一个丝氨酸蛋白酶，作为补体激活的凝集素途径的组成部分。补体途径在天然和适应性免疫应答中起基本作用。编码的蛋白质作为酶原合成，并与凝集素途径的病原体识别分子甘露糖结合凝集素和纤维连蛋白复合物时激活。该蛋白质不直接参与补体激活，但可以通过切割补体C2或激活另一个补体丝氨酸蛋白酶MASP-2来作为补体激活的放大器。该编码的蛋白质还能切割纤维蛋白原和因子XIII，可能涉及凝血过程。这个基因的缺失丝氨酸蛋白酶结构域的剪接变体作为补体途径的抑制剂。交替剪接产生多个转录变异体。[RefSeq，2010年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MASP1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
