Log In|Sign Up
中文人类
MAP2K3 - Mitogen-activated Protein Kinase Kinase 3
Alias:
MEK3
MKK3
MAPKK3
PRKMK3
SAPKK2
SAPKK-2
Favorite
这个基因编码的蛋白质是一种属于MAP激酶激酶家族的双向特异性蛋白激酶。这种激酶由有丝分裂和环境应激激活，并参与MAP激酶介导的信号级联。它可以磷酸化并因此激活MAPK14/p38-MAPK。这种激酶可以被胰岛素激活，对于葡萄糖转运体的表达是必需的。RAS癌基因的表达被发现会导致这种激酶的活性形式的积累，从而导致MAPK14的组成性激活，并赋予原代细胞的癌基因转化。这种激酶的抑制与假结核耶尔森菌的病理发生有关。已经在这个基因中报道了许多可变剪接的转录变异体，它们编码不同的异构体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAP2K3 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
