人类

MAPK10 - Mitogen-activated Protein Kinase 10

Alias:
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是MAP激酶家族的成员。MAP激酶作为多个生物化学信号的整合点,参与多种细胞过程,如增殖、分化、转录调节和发育。这个激酶在神经系统的一组特定神经元中特异地表达,并通过苏氨酸和酪氨酸磷酸化激活。小鼠中这个基因的定向缺失提示它可能参与应激诱导的神经元凋亡。这个基因的不同剪接转录变异体已经描述过,它们编码不同的异构体。最近的一项研究提供了这个基因中翻译读穿的证据,并通过使用一个替代的帧内翻译终止密码子表达了额外的C-末端延伸的异构体。[RefSeq,2017年12月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
14
14
583670 bp
52.59
18
1
5
17

MAPK10 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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