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中文人类
MAPK8 - Mitogen-activated Protein Kinase 8
Alias:
JNK
JNK1
PRKM8
SAPK1
JNK-46
JNK1A2
SAPK1c
JNK21B1/2
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这个基因编码的蛋白质是MAP激酶家族的成员。MAP激酶作为多个生物化学信号的整合点，参与多种细胞过程，如增殖、分化、转录调节和发育。这个激酶受到各种细胞刺激的激活，并靶向特定的转录因子，从而调节细胞刺激反应中的即时早期基因表达。肿瘤坏死因子α（TNF-α）激活这个激酶被证明是TNF-α诱导的凋亡所必需的。这个激酶也参与紫外线辐射诱导的凋亡，被认为与细胞色素c介导的细胞死亡途径有关。这个基因的鼠科对应物的研究提示这个激酶在T细胞增殖、凋亡和分化中起关键作用。已经报道了几种编码不同异构体的可变剪接转录变异体。[由RefSeq，2016年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAPK8 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
