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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
MAPK1 - Mitogen-activated Protein Kinase 1
Alias:
ERK
p38
p40
p41
ERK2
ERT1
NS13
ERK-2
MAPK2
PRKM1
PRKM2
P42MAPK
p41mapk
p42-MAPK
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个MAP激酶家族的成员。MAP激酶,也称为细胞外信号调节激酶(ERKs),作为多个生物化学信号的整合点,参与多种细胞过程,如增殖、分化、转录调节和发育。这个激酶的激活需要其被上游激酶磷酸化。激活后,这个激酶转移到受刺激细胞的细胞核中,在那里它磷酸化核靶标。一项研究还表明,这种蛋白质可以作为独立于其激酶活性的转录抑制子发挥作用。根据其执行机制上不同的功能的能力,该编码的蛋白质已被鉴定为兼职蛋白质。已经为这个基因报道了两个可选择的剪接转录变异体,它们编码相同的蛋白质,但在UTRs上不同。[由RefSeq,2014年1月提供]
Related ID:
NCBI:5594
ENSEMBL:ENSG00000100030
HGNC:6871
UNIPROT:P28482
OMIM:176948
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5594
2
9
108024 bp
41.39
34
4
16
73
MAPK1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
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Name
MGI
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CAS Number
Status
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References Literature
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