人类

MAPK1 - Mitogen-activated Protein Kinase 1

Alias:
ERK
p38
p40
p41
ERK2
ERT1
NS13
ERK-2
MAPK2
PRKM1
PRKM2
P42MAPK
p41mapk
p42-MAPK
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个MAP激酶家族的成员。MAP激酶,也称为细胞外信号调节激酶(ERKs),作为多个生物化学信号的整合点,参与多种细胞过程,如增殖、分化、转录调节和发育。这个激酶的激活需要其被上游激酶磷酸化。激活后,这个激酶转移到受刺激细胞的细胞核中,在那里它磷酸化核靶标。一项研究还表明,这种蛋白质可以作为独立于其激酶活性的转录抑制子发挥作用。根据其执行机制上不同的功能的能力,该编码的蛋白质已被鉴定为兼职蛋白质。已经为这个基因报道了两个可选择的剪接转录变异体,它们编码相同的蛋白质,但在UTRs上不同。[由RefSeq,2014年1月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
9
108024 bp
41.39
34
4
16
73

MAPK1 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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