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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PRKCQ - Protein Kinase C Theta
Alias:
PRKCT
nPKC-theta
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
蛋白激酶C(PKC)是一类特异性的丝氨酸和苏氨酸蛋白激酶家族,可以通过钙离子和第二信使二酯酰甘油激活。PKC家族成员可以磷酸化各种蛋白质靶标,并已知参与多种细胞信号传导途径。PKC家族成员还作为佛波酯类的一类肿瘤促进剂的主要受体。PKC家族每个成员都有特定的表达模式,并被认为扮演独特的角色。这个基因编码的蛋白质是PKC家族成员之一。它是一种不依赖于钙离子且依赖于磷脂的蛋白激酶。这种激酶对于T细胞的激活是必要的。它对于转录因子NF-kappa B和AP-1的激活是必要的,并且可能将T细胞受体(TCR)信号复合体与转录因子的激活联系起来。[由RefSeq,2008年7月提供]
Related ID:
NCBI:5588
ENSEMBL:ENSG00000065675
HGNC:9410
UNIPROT:Q04759
OMIM:600448
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5588
9
18
186550 bp
81.86
27
1
10
36
PRKCQ Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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