人类

PRKCI - Protein Kinase C Iota

Alias:
PKCI
DXS1179E
nPKC-iota
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个蛋白激酶C(PKC)家族的丝氨酸/苏氨酸蛋白激酶成员。PKC家族至少有8个成员,它们在不同表达水平上参与多种细胞过程。这个蛋白激酶不依赖于钙,而依赖于磷脂。它不被佛波醇酯或二酸甘油酯激活。这个激酶可以通过与小型GTP酶RAB2的直接相互作用被招募到囊泡管状簇(VTCs)中,在那里这个激酶磷酸化甘油醛-3-磷酸脱氢酶(GAPD/GAPDH),并在早期分泌途径中的微管动力学中发挥作用。这个激酶被发现在BCL-ABL介导的对药物诱导的凋亡的抗性中是必要的,因此保护白血病细胞免受药物诱导的凋亡。在染色体X上有一个单外显子假基因。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3
18
83554 bp
68.26
14
--
15
43

PRKCI Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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