Home
Toolbox
Resource
Workflow
Tutorials
Citations
Downloads
Mutation Al-Predictor Flow
Gene-to-Mutation Flow
News & Insights
Genetic Encyclopedia
Frontiers
Industry Insights
Case Studies
About Us
About the Site
Contact Us
Private Policy
User Agreement
COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
Log In
|
Sign Up
中文
人类
PRKCI - Protein Kinase C Iota
Alias:
PKCI
DXS1179E
nPKC-iota
新建收藏夹
取消
确认
加入收藏夹
选择一个收藏夹
描述信息
新收藏夹 >>
取消
确认
加入收藏
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个蛋白激酶C(PKC)家族的丝氨酸/苏氨酸蛋白激酶成员。PKC家族至少有8个成员,它们在不同表达水平上参与多种细胞过程。这个蛋白激酶不依赖于钙,而依赖于磷脂。它不被佛波醇酯或二酸甘油酯激活。这个激酶可以通过与小型GTP酶RAB2的直接相互作用被招募到囊泡管状簇(VTCs)中,在那里这个激酶磷酸化甘油醛-3-磷酸脱氢酶(GAPD/GAPDH),并在早期分泌途径中的微管动力学中发挥作用。这个激酶被发现在BCL-ABL介导的对药物诱导的凋亡的抗性中是必要的,因此保护白血病细胞免受药物诱导的凋亡。在染色体X上有一个单外显子假基因。[由RefSeq,2008年7月提供]
Related ID:
NCBI:5584
ENSEMBL:ENSG00000163558
HGNC:9404
UNIPROT:P41743
OMIM:600539
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5584
3
18
83554 bp
68.26
14
--
15
43
PRKCI Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Reset
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top