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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
AXL - AXL Receptor Tyrosine Kinase
Alias:
ARK
UFO
JTK11
Tyro7
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Tyro3-Axl-Mer(TAM)受体酪氨酸激酶亚家族的成员。编码的蛋白质具有一个细胞外结构域,该结构域由N端的两个免疫球蛋白样基序组成,后面跟着两个纤维连接蛋白型III基序。它通过结合维生素K依赖性蛋白质生长抑制特异性6(Gas6)将信号从细胞外基质传递到细胞质中。这个基因可能参与多种细胞功能,包括多种细胞类型中的生长、迁移、聚集和抗炎。编码的蛋白质作为多种病毒的宿主细胞受体,包括马尔堡、埃博拉和拉沙病毒,并且是SARS-CoV2病毒的候选受体。[由RefSeq,2021年9月提供]
Related ID:
NCBI:558
ENSEMBL:ENSG00000167601
HGNC:905
UNIPROT:P30530
OMIM:109135
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
558
3
20
42544 bp
98.34
155
1
10
32
AXL Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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