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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PRKCA - Protein Kinase C Alpha
Alias:
AAG6
PKCA
PRKACA
PKCI+/-
PKCalpha
PKC-alpha
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
蛋白激酶C(PKC)是一类特异性的丝氨酸和苏氨酸蛋白激酶家族,可以通过钙离子和第二信使二酯酰甘油激活。PKC家族成员可以磷酸化各种蛋白质靶标,并已知参与多种细胞信号传导途径。PKC家族成员还作为佛波酯类的一类肿瘤促进剂的主要受体。PKC家族每个成员都有特定的表达模式,并被认为在细胞中扮演独特的角色。这个基因编码的蛋白质是PKC家族成员之一。这个激酶已被报道在许多不同的细胞过程中发挥作用,如细胞粘附、细胞转化、细胞周期检查点以及细胞体积控制。在小鼠中的敲除研究表明,这个激酶可能是心肌细胞中心脏收缩性和Ca(2)处理的基本调节因子。[RefSeq,2008年7月提供]
Related ID:
NCBI:5578
ENSEMBL:ENSG00000154229
HGNC:9393
UNIPROT:P17252
OMIM:176960
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
5578
7
17
508131 bp
76.75
25
--
7
44
PRKCA Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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