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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PRG2 - Proteoglycan 2, Pro Eosinophil Major Basic Protein
Alias:
MBP
BMPG
MBP1
proMBP
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是嗜酸性粒细胞颗粒晶核的主要成分。这个蛋白质的前体在胎盘和妊娠血清中含量也很高,它与其他几种蛋白质(包括妊娠相关血浆蛋白A(PAPPA)、血管紧张素原(AGT)和C3dg)形成一个复合物。这个蛋白质可能参与抗寄生虫防御机制,作为一种细胞毒素和寄生虫毒素,以及免疫超敏反应。编码的蛋白质含有一个展示出对革兰氏阳性细菌、革兰氏阴性细菌和小菌株具有强大抗菌活性的肽。它直接导致上皮细胞损伤、脱落和过敏性疾病的支气管痉挛。已经发现这个基因有不同的剪接转录变异体,它们编码不同的异构体。[RefSeq,2014年11月提供]
Related ID:
NCBI:5553
ENSEMBL:ENSG00000186652
HGNC:9362
UNIPROT:P13727
OMIM:605601
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
5553
4
6
3871 bp
25.21
13
--
6
29
PRG2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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