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中文人类
NUDT15 - Nudix Hydrolase 15
Alias:
MTH2
NUDT15D
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这个基因编码一种属于Nudix水解酶超家族的酶。这个超家族的成员催化核苷酸二磷酸的水解，包括像8-氧代-dGTP这样的底物，这是氧化损伤的结果，可能在DNA复制过程中导致碱基错配，导致转换。编码的酶是硫嘌呤活化和毒性的负调控因子。这个基因的突变导致硫嘌呤代谢不良，与硫嘌呤诱导的早期白细胞减少症有关。已经发现了这个基因的多个假基因。[RefSeq，2016年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NUDT15 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
