人类

PPM1B - Protein Phosphatase, Mg2+/Mn2+ Dependent 1B

Alias:
PP2CB
PP2CBETA
PP2C-beta
PPC2BETAX
PP2C-beta-X
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Ser/Thr蛋白磷酸酶PP2C家族的成员。PP2C家族成员已知是细胞应激响应途径的负调控因子。这个磷酸酶已被证明可以脱磷酸化细胞周期蛋白依赖性激酶(CDKs),因此可能涉及细胞周期控制。过表达这个磷酸酶已被报道会导致细胞生长停滞或细胞死亡。可变剪接产生多个转录变异体,编码不同的异构体。其他转录变异体已被描述,但目前不代表完整的长序列。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
8
6
78054 bp
52.64
22
1
5
16

PPM1B Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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