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中文人类
PPM1A - Protein Phosphatase, Mg2+/Mn2+ Dependent 1A
Alias:
PP2CA
PP2Calpha
PP2C-ALPHA
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这个基因编码的蛋白质是Ser/Thr蛋白磷酸酶PP2C家族的成员。PP2C家族成员已知是细胞应激响应途径的负调控因子。这个磷酸酶可以脱磷酸化并负调控MAP激酶和MAP激酶激酶的活性。已经证明它可以抑制环境应力诱导的p38和JNK激酶级联激活。这个磷酸酶还可以脱磷酸化细胞周期依赖性激酶，从而可能涉及细胞周期控制。过表达这个磷酸酶已被报道可以激活肿瘤抑制基因TP53/p53的表达，导致G2/M细胞周期停滞和凋亡。已经描述了三种可变剪接转录变异体，它们编码不同的异构体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PPM1A Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
