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中文人类
RNF43 - Ring Finger Protein 43
Alias:
URCC
SSPCS
RNF124
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这个基因编码的蛋白质是一种RING型的E3泛素连接酶，预测含有跨膜结构域、蛋白酶相关结构域、外域和胞质RING结构域。这个蛋白质被认为负调控Wnt信号通路，这个基因的表达导致frizzled受体的泛素化增加，其亚细胞分布改变，导致这些受体的表面水平降低。这个基因的突变已在多种肿瘤细胞中报道，包括结肠直肠癌和子宫内膜癌。可变剪接导致多个转录变异体，编码不同的异构体。[RefSeq,2015年3月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
RNF43 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
