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中文人类
PGPEP1 - Pyroglutamyl-peptidase I
Alias:
PGI
PGP
Pcp
PGPI
PAP-I
PGP-I
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这个基因编码一个半胱氨酸蛋白酶，属于肽酶C15家族的蛋白质成员。编码的蛋白质从包括促甲状腺素释放激素和其他神经肽的蛋白质底物中切割氨基末端吡咯氨酸残基。这个基因在结直肠癌中的表达可能被下调，而其编码的蛋白质的活性可能与结直肠癌患者的癌症进展呈负相关。编码的蛋白酶的活性在其他疾病状态中也可能改变，包括与蛋白酶活性降低相关的肝硬化，以及与蛋白酶活性升高的无精子症。[由RefSeq，2016年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PGPEP1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
