Ccdc22 - coiled-coil domain containing 22

Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cytoplasmic sequestering of NF-kappaB; regulation of I-kappaB kinase/NF-kappaB signaling; and vesicle-mediated transport to the plasma membrane. Predicted to act upstream of or within cholesterol homeostasis and regulation of plasma lipoprotein particle levels. Predicted to be located in endosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]