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中文人类
ING3 - Inhibitor Of Growth Family Member 3
Alias:
Eaf4
ING2
MEAF4
p47ING3
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这个基因编码的蛋白质与ING1相似，ING1是一种可以与TP53相互作用、抑制细胞生长并诱导凋亡的肿瘤抑制子蛋白质。这个蛋白质包含一个PHD指环，这是一个在涉及染色质重塑的蛋白质中常见的基序。这个基因可以激活p53反式激活的启动子，包括p21/waf1和bax的启动子。过表达这个基因已被证明可以抑制细胞生长并诱导凋亡。这个基因的等位基因丢失和减少的表达在头颈部癌症中被发现。已经观察到了编码不同异构体的两种可变剪接转录本变异体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ING3 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
