Irf7 - interferon regulatory factor 7

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to other organism; positive regulation of transcription, DNA-templated; and regulation of toll-like receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]