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中文人类
GSAP - Gamma-secretase Activating Protein
Alias:
PION
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阿尔茨海默病（AD；MIM 104300）的主要特征是神经毒素类淀粉样β的积累。类淀粉样β的形成是由γ-分泌酶（参见PSEN1；MIM 104311）催化，这是一种具有多种底物的蛋白酶。PION或GSAP通过与其底物，即类淀粉样β前体蛋白（APP；MIM 104760）C端片段（APP-CTF）相互作用的选择性增加类淀粉样β的产生（He等人，2010年[PubMed 20811458]）。[由OMIM于2010年11月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GSAP Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
