小鼠

Cldn7 - claudin 7

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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码claudin家族的一员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞片之间的胞间间隙。它们还在维持细胞极性和信号传导中起到关键作用。这个基因在整个发育过程中在乳腺上皮中组成性表达,可能涉及囊泡向基底侧膜的转运。它对远端肾小管的NaCl稳态是必不可少的。缺乏这个基因的敲除小鼠表现出严重的盐浪费、慢性脱水、生长迟缓,并在出生后12天内死亡。已经发现了这个基因的可变剪接转录变异体。[RefSeq,2010年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
2
4
3108 bp
22.36
3
6

Cldn7 Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

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Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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