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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Cldn7 - claudin 7
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码claudin家族的一员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞片之间的胞间间隙。它们还在维持细胞极性和信号传导中起到关键作用。这个基因在整个发育过程中在乳腺上皮中组成性表达,可能涉及囊泡向基底侧膜的转运。它对远端肾小管的NaCl稳态是必不可少的。缺乏这个基因的敲除小鼠表现出严重的盐浪费、慢性脱水、生长迟缓,并在出生后12天内死亡。已经发现了这个基因的可变剪接转录变异体。[RefSeq,2010年8月提供]
Related ID:
NCBI:53624
ENSEMBL:ENSMUSG00000018569
UNIPROT:Q9Z261
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
53624
2
4
3108 bp
22.36
3
6
Cldn7 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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