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中文人类
PLCG1 - Phospholipase C Gamma 1
Alias:
PLC1
NCKAP3
PLC-II
PLC148
PLCgamma1
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这个基因编码的蛋白质催化磷脂酰肌醇4,5-二磷酸酯形成肌醇1,4,5-三磷酸酯和二酸甘油酯。这个反应使用钙作为辅因子，并在细胞内受体介导的酪氨酸激酶激活物的细胞内转导中扮演重要角色。例如，当被SRC激活时，编码的蛋白质导致Ras鸟苷酸交换因子RasGRP1转移到高尔基体，在那里激活Ras。此外，这个蛋白质已被证明是肝素结合生长因子1（酸性成纤维细胞生长因子）激活的酪氨酸激酶的主要底物。已经发现这个基因有两个编码不同异型的转录变异体。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PLCG1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
