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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PLAUR - Plasminogen Activator, Urokinase Receptor
Alias:
CD87
UPAR
URKR
U-PAR
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码尿激酶纤溶酶原激活物的受体,其作用是定位并促进纤溶酶的形成,可能影响到许多与细胞表面纤溶酶原激活和细胞外基质局部降解相关的正常和病理过程。它既能与尿激酶纤溶酶原激活物的成熟形式也能与前体蛋白结合,并通过纤溶酶激活结合在受体上的前酶。该蛋白缺乏跨膜或细胞质结构域,可能在其羧基端附近的新生多肽被切割后通过糖基-磷酯肌醇(GPI)部分锚定到质膜上。然而,在某些细胞类型中也会产生可溶性的蛋白。可变剪接产生了多种编码不同异型体的转录变异体。前体蛋白经历了一些翻译后的切割反应,但这些反应尚未完全定义。[由RefSeq,2008年7月提供]
Related ID:
NCBI:5329
ENSEMBL:ENSG00000011422
HGNC:9053
UNIPROT:Q03405
OMIM:173391
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
5329
18
7
24075 bp
36.98
23
--
7
23
PLAUR Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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