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中文人类
PLAU - Plasminogen Activator, Urokinase
Alias:
ATF
QPD
UPA
URK
u-PA
BDPLT5
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这个基因编码一种分泌性的丝氨酸蛋白酶，能将血浆酶原转化为血浆酶。编码的前原蛋白在蛋白水解过程中被加工成A和B多肽链。这些链通过一个二硫键结合形成无活性的高分子量尿激酶型血浆酶激活剂（HMW-uPA）。HMW-uPA可以进一步加工成有活性的低分子量尿激酶型血浆酶激活剂（LMW-uPA）。这种低分子量形式不与尿激酶型血浆酶激活剂受体结合。这个基因的突变可能与魁北克血小板紊乱和晚发性阿尔茨海默病有关。可变剪接导致多个转录变异体，至少其中一个编码一种经过蛋白水解加工的异构体。[RefSeq，2016年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PLAU Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
