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中文人类
PLAT - Plasminogen Activator, Tissue Type
Alias:
TPA
T-PA
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这个基因编码组织型纤溶酶原激活物，一种分泌的丝氨酸蛋白酶，将纤溶酶原前酶转化为纤溶酶，一种纤维蛋白溶解酶。编码的前原蛋白被纤溶酶或胰蛋白酶蛋白水解处理，生成重链和轻链。这些链通过二硫键关联形成异源二聚酶。这种酶在细胞迁移和组织重塑中发挥作用。酶活性增加导致高纤维蛋白溶解，表现为过度出血，而活性降低导致纤维蛋白溶解减少，可能导致血栓形成或栓塞。这个基因的可变剪接导致多个转录变异体，至少其中一个编码经蛋白水解处理的异构体。[RefSeq，2016年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PLAT Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
