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中文人类
PIM1 - Pim-1 Proto-oncogene, Serine/threonine Kinase
Alias:
PIM
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这个基因编码的蛋白质属于Ser/Thr蛋白激酶家族，PIM亚家族。这个基因主要在B淋巴细胞和髓细胞系中表达，在造血恶性肿瘤和前列腺癌中过表达。它在血液细胞的信号传导中发挥作用，促进细胞增殖和生存，从而在肿瘤发生中提供选择性优势。人和正态小鼠的基因已报道编码两种异构体（具有优先的细胞定位），这是由于使用上游非AUG（CUG）和下游AUG密码子的可选框内翻译起始密码子（PMIDs:16186805, 1825810）。[RefSeq，2011年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PIM1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
