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中文人类
PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
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这个基因编码的蛋白质是四种调节糖酵解副产物2,6-二磷酸果糖(F2,6BP)浓度的双功能激酶/磷酸酶之一。该编码蛋白质在癌细胞中高度表达，并在缺氧时被诱导。该蛋白质在缺氧条件下对癌细胞生存是必不可少的，因为它在细胞无法产生大量F2,6BP和ATP时增加了F2,6BP和ATP的量。这一发现表明，该蛋白质可能成为癌细胞中的破坏的好靶点，从而威胁其生存。已发现该基因编码不同异构体的几种转录变异体。[RefSeq,2015年11月提供]
Basic Information
NCBI
Transcripts
Exons
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Mutations
Related Diseases
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PFKFB4 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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Transcript
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CDS(bp)
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Cell-specific RNA expression
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References Literature
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